Formulation and evaluation of Clopidogrel bisulfate loaded transdermal patches for anti-platelet activity
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چکیده
منابع مشابه
Formulation and Evaluation of Transdermal Drug Delivery System of Clopidogrel Bisulfate
Transdermal drug delivery is an alternative route for systemic drug delivery which minimizes the absorption and increases the bioavailability. Orally Clopidogrel bisulfate has a short elimination half-life (7-8 hrs.), low oral bioavailability (50%) undergoes extensive first pass metabolism (85%) and frequent high doses (75 mg) are required to maintain the therapeutic level as a result, dose dev...
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Many patients especially children and elderly have difficulty in swallowing tablets and capsules and consequently unable to take medicine as prescribed. Almost 50% of the population is affected by such problem, resulting in the high incidence of non compliance and ineffective therapy. Most pharmaceutical forms for oral administration are formulated for direct ingestion, or for chewing, or for p...
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Drug Delivery through skin would provide a useful alternative to oral delivery, which has numerous side effects. Therefore, the present investigation was aimed to develop sustained release transdermal therapeutics system containing Glipizide with varying ratios of HPMC & PVPK30 using solvent evaporation technique. Ten different formulations were prepared keeping the concentration of Glipizide c...
متن کاملFormulation, Optimization & Evaluation of Transdermal Patches of Salbutamol Sulphate
Aim: The objective of the present research work was to formulate and compare two different kinds of penetration enhancer in transdermal patch with placebo patch using a drug (Salbutamol sulphate) and compare for in vitro drug release. Study Design: The transdermal patches of Salbutamol sulphate were prepared by solvent evaporation technique using different ratios of Hydroxy propyl methylcellulo...
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The aim of this research was to formulate a matrix-type transdermal therapeutic system containing drug ciprofloxacin with different ratios of hydrophobic (ethyl cellulose) polymer by solvent evaporation technique, using 15% w/w of dibutyl phthalate to the polymer weight, incorporated as plasticizer. Different concentrations of isopropyl myristate were used to enhance the transdermal permeation ...
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ژورنال
عنوان ژورنال: International Journal of Research in Pharmaceutical Sciences
سال: 2018
ISSN: 0975-7538
DOI: 10.26452/ijrps.v9i1.1153